The skin is the largest body organ and functions as the metabolically active biological barrier. The skin shows remarkable structural and functional diversity as it is continuously exposed to external factors, e.g. solar and thermal radiation, changes in humidity, as well as insidious mechanical, chemical, and biological influences. The maintenance and protection of the skin is therefore highly critical and requires prophylactic and curative measures.

Anatomy and histology
The skin is composed of two main layers: the epidermis and the dermis. The structure and thickness of both vary according to anatomic location. Epidermis and dermis are very important barriers against the penetration of external factors such as cosmetic and pharmaceutical products. The skin manages immune reactions by its own immune system hosted in various cell populations. 

Neuroendocrine signals 
Skin residents and immune cells express receptors for neuropeptides and neurotransmitters. The endocrine mediators with their receptors are organized into dermal and epidermal units. The skin neuroendocrine system communicates with itself and with the systemic level through humoral and neural pathways to induce various changes such as immune reactions and pigmentation. The skin is also involved in the formation of steroids and the conversion of sex and thyroid hormones. Our research activities are structured to explore the action and interaction of locally applied Melatonin in diverse carrier systems. For further information please contact ASATONA AG hwschmid@asatona.com